References
Disclaimer: IsoQuac does not rely on CONSTANd normalisation as described in reference 2. Instead, an IPFP algorithm is used for matrix normalisation. The row and column constrains are set to the values described in reference 4 to allow for unbalanced isobaric cassettes, i.e., different sample multiplexes can be compared.
If you use IsoQuaC in your research, please cite the following publications:
- QCQuan: A Web Tool for the Automated Assessment of Protein Expression and Data Quality of Labeled Mass Spectrometry Experiments
- CONSTANd : A Normalization Method for Isobaric Labeled Spectra by Constrained Optimization
- Detecting significant changes in protein abundance
- Constrained Standardization of Count Data from Massive Parallel Sequencing